NMR studies on 4-thio-5-furan-modified and 4-thio-5-thiophene-modified nucleosides
نویسندگان
چکیده
منابع مشابه
rac-Ethyl 4-hydroxy-4-trifluoromethyl-6-(2,4,5-trimethoxyphenyl)-2-thio-1,3-diazinane-5-carboxylate
In the title compound, C(17)H(21)F(3)N(2)O(6)S, the hexa-hydro-pyrimidine ring adopts a half-chair conformation: the mean plane formed by the ring atoms excluding the C atom bonded to the eth-oxy-carbonyl group has an r.m.s. deviation of 0.0427 Å and forms a dihedral angle of 66.41 (5)° with the benzene ring. The mol-ecular conformation is stabilized by an intra-molecular hydroxyl O-H⋯O(carbox-...
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5-Substituted-4-thio-2'-deoxyuridine nucleosides have been chemically synthesized and studied by NMR and UV spectroscopy. The results have been analyzed and discussed in connection with the previous data. The imino proton signal and the carbon signal of the thiocarbonyl group in the 5-substituted-4-thio-2'-deoxyuridines were found to be at much lower field, offering a potential for monitoring t...
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Phosphorothioate modification is one of the most widely investigated and promising chemical modifications in oligonucleotide (ON) based therapeutics. Structurally similar 5'-thio or phosphorothiolate-modified nucleotides, in which a 5'-bridging oxygen is replaced with a sulfur atom, are gaining importance for ON-based research. Several reports have been published describing the synthesis of 5'-...
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Three homologous series of polymethylene-a,i<;-bis[2-thio-5(4’,4'’n-alkoxybenzoyloxy)phenyl]-l,3,4-oxadiazole (series 5 a, b, c), are reported.The compounds have identical mesogenic units at both ends of a spacer (i.e. they are twins). These twins possess a spacer of 6, 8 and 10 carbon atoms joined directly to the oxadiazole ring through sulphur atoms. The lateral alkylic chains vary between 6 ...
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The synthesis of some triazole derivatives starting from 4methyl-phenoloxyacetyl hydrazide is described. In this process, the method for the synthesis of 2-chloroacetanilide had been improved and good yields have been obtained. The chemical structure of all compounds have been elucidated by IR, H NMR, C NMR and elemental analysis studies. All of the compounds have been investigated for plant gr...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Chemistry
سال: 2016
ISSN: 0749-1581
DOI: 10.1002/mrc.4501